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Contaminants in the Urban Environment: Pharmaceuticals and Personal Care Products (PPCPs)—Part 1

Yun-Ya Yang, Gurpal S. Toor, and Alexander J. Reisinger

This publication is part of a series titled Contaminants in the Urban Environment. This series is intended to give state and local government officials, soil scientists, consulting engineers, extension agents, and citizens (1) a basic understanding of the occurrence, toxic effects, and source of various contaminants in the environment and (2) guidance on ways to protect human and environmental health.

Introduction and Purpose

Pharmaceuticals are products that we ingest or give to our pets and domesticated animals to improve health and to prevent or treat human and animal diseases. Pharmaceuticals include over-the-counter drugs, prescription medicines, nutritional supplements, and veterinary drugs.

Personal care products are products used to improve the quality of daily life by adorning and cleaning our bodies. Personal care products include lotions, fragrances, shampoos, antibacterial soaps, detergents, sunscreens, insect repellents, and cosmetics.

Together, these products are known as pharmaceuticals and personal care products, abbreviated as PPCPs (Figure 1).

Figure 1. Common pharmaceutical and personal care products (PPCPs) in households
Figure 1 . Common pharmaceutical and personal care products (PPCPs) in households. Credit: iStock/Thinkstock.com 

This publication, Contaminants in the Urban Environment: Pharmaceuticals and Personal Care Products (PPCPs)—Part 1, provides an overview of the use and sale of PPCPs in the United States and the world. The second publication, Contaminants in the Urban Environment: Pharmaceuticals and Personal Care Products (PPCPs)—Part 2, discusses the sources and impacts of PPCPs as well as the ways to protect our environment from PPCPs (https://edis.ifas.ufl.edu/publication/ss633).

Use of Pharmaceuticals and Personal Care Products (PPCPs)

Pharmaceuticals: Pharmaceuticals can be broadly split into two groups: (1) over-the-counter medications that do not require a doctor's prescription and (2) medications that require a doctor's prescription. In the United States and the rest of the world, most of the medication use (sale) is for the prescription medicines.

(1) Over-the-Counter (OTC) Medications: In 2012, OTC medications (both for oral ingestion and topical use) worth $23 billion were sold in the United States. Sales of OTC PPCPs expanded to more than $34 billion in the US in 2017. Cold, pain, and heartburn medications were the top categories (see Table 1).

(2) Prescription Medications: In 2016, global prescription pharmaceutical sales were estimated at $967 billion, with 46% ($446 billion) of those sales occurring in the United States (Lindsley 2017), which is more than 13 times the OTC medications sold ($34 billion).

Table 2 shows the top 10 prescription medications sold in the United States ranked by retail sales estimates and number of monthly prescriptions from May 2014 through April 2015. The top 10 medications sold in the United States had a value of about $60 billion. In the United States in 2012, the top three therapeutic classes of medications were hypertension ($656 million), pain ($472 million), and mental ($329 million; Figure 2). Looking at the worldwide trends, the top three therapeutic classes of medications were oncology, pain, and hypertension.

Figure 2. Sale of pharmaceutical based on therapeutic classes (a) worldwide and (b) in the United States
Figure 2.  Sale of pharmaceutical based on therapeutic classes (a) worldwide and (b) in the United States.
Credit: https://www.iqvia.com and https://www.drugs.com/stats/top100/2012/sales

In the U.S. in 2004, there were 3.5 billion prescriptions filled, or 11.9 prescriptions filled per person (Muson and Townsend 2009). The types of prescription medications most commonly used in the U.S. vary with age (Gu et al. 2010)—asthma medications for children (ages 0–11), central nervous system stimulants for adolescents (12–19), antidepressants for middle-aged adults (20–59), and cholesterol lowering and high blood pressure drugs for older Americans (60 and older).

The data on medication sales provide some perspective on how we use medications. For example, throughout the last decade the percentage of Americans who indicated they had used one prescription medication in the previous month increased by 4%, the use of multiple prescription medications increased by 6%, and the use of five or more medications increased by 5% (Gu et al. 2010).

Patients using prescription medications varied by age and gender. Data in Figure 3 shows that prescription use increased during the three time periods (1988–1994, 1999–2002, and 2007–2010). For example, men 65 years and older who claimed to have used three or more prescriptions in the previous month was 30% in 1988–1994, but this percentage increased to 45% in 1999–2002 and to 65% in 2007–2010. For women 65 years and order, the use of three or more prescriptions in the previous month was 38% in 1988–1994, and this percentage increased to 55% in 1999–2002 and to 65% in 2007–2010. Based on these statistics, women were more likely to use medications than men (Figure 3). During the three time periods, patient use of prescription medications increased with age: 5% for children, 10%–40% for working aged adults, and 30%–70% for adults aged 65 and over.

Overall, the use of three or more prescription medications in the previous month increased for all age groups of both males and females from 1988–1994 to 2007–2010.

Figure 3. Use of three or more prescription medications in the previous month, by gender and age in the United States
Figure 3 . Use of three or more prescription medications in the previous month, by gender and age in the United States. Credit: Credit: National Center for Health Statistics (CDC/NCHS). Health, United States, 2012. Data from the National Health and Nutrition Examination Survey 

Consider that the United States is home to approximately 5 percent of the total world population and this population uses about 39 percent of total prescription medication sales. Generally, a higher amount of a given medicine is prescribed and used so that there is a sufficient amount of medicine to work in the body and cure the symptoms or disease. A higher amount of medicine intake results in a greater amount of medicine excretion, either as the parent compound or as transformation products (or metabolites) in feces and urine. For example, research shows that of the total medicine taken, about 19%–22% is excreted as parent compound and an additional 3%–49% is excreted as metabolites in the urine and feces (Lienert et al. 2007). Thus, the household wastewater that contains feces and urine ends up containing pharmaceutical compounds and becomes a source of the parent medicine or its metabolites in the environment.

Personal Care Products: Many people use personal care products on a daily basis, be it hair or skin care products. The total global sale of personal care products was $380 billion in 2010. It is estimated that spending on personal care products will continue to grow by 3% per year (Rexam 2011).

As shown in Figure 4, in 2010 worldwide hair care products were the number one seller ($152 billion; 40% of total), followed by bath and shower products ($91 billion; 24% of total), and facial skin care products ($19 billion; 5% of total). In the global market of personal care products, the Asia-Pacific region has the largest share (56%), followed by Europe (19%), Latin America (14%), North America (8%), and Middle East and Africa (2%).

Figure 4. Total global sales of personal care products in 2010
Figure 4.  Total global sales of personal care products in 2010.
Credit: Rexam (2011)

Figure 5 shows that in the United States in 2013, skin care products sales were $9.8 billion, followed by hair care products ($7.8 billion) and makeup products ($6.5 billion). Note that in comparison to sale of $330 billion on prescription and $23 billion on OTC medications, consumers in the United States spend far less (~$30 billion) on personal care products.

Figure 5. Projected dollar sales of the US cosmetics and toiletries industry by product class, 2008 to 2013
Figure 5.  Projected dollar sales of the US cosmetics and toiletries industry by product class, 2008 to 2013.
Credit: Kline & Company

Personal care products contain a variety of chemical substances. For example, phthalates are a group of compounds widely used in cosmetics, fragrances, hair products, and shampoo. Triclosan is one example of a widely used antibacterial and antifungal agent. Triclosan is commonly present as an additive in a variety of consumer products, including soaps, deodorants, and toothpastes. For example, liquid soap may contain 0.3 to 0.5 percent of triclosan. In 2017, however, the US Food and Drug Administration (FDA) banned the development and marketing of OTC products that use triclosan and certain other antiseptic compounds, effectively removing tricoslan from the US market. Many of the products, and compounds they contain, enter household wastewater from bath and shower, sinks, and washers and ultimately find their way into the environment. Continuous discharge of wastewater contributes to the accumulation of these substances in the environment.

Because of the presence of these substances, PPCPs discarded into the environment can be harmful to organisms. For example, triclosan and its transformation products have been found in water, plant, and fish samples; and they may have adverse effects on algal communities and aquatic organisms (Wilson et al. 2003). Consult the second publication, Contaminants in the Urban Environment: Pharmaceuticals and Personal Care Products (PPCPs)—Part 2 (https://edis.ifas.ufl.edu/publication/ss633) to learn about these harmful effects along with ways to protect ourselves and our environment.

References

Gu, Q., C. F. Dillon, and V. L. Burt. 2010. "Prescription Drug Use Continues to Increase: U.S. Prescription Drug Data for 2007–2008." NCHS Data Brief, no 42. Hyattsville, MD: National Center for Health Statistics.

IQVIA Institute for Human Data Science. 2019. The Global Use of Medicine in 2019 and Outlook to 2023. https://informatori.it/wp-content/uploads/2019/03/the-global-use-of-medicine-in-2019-and-outlook-to-2023.pdf accessed 14 July 2022.

IQVIA Institute for Human Data Science. 2020. Medicine Spending and Affordability in the United States. https://heatinformatics.com/sites/default/files/images-videosFileContent/medicine-spending-and-affordability-in-the-united-states%20%281%29.pdf accessed 14 July 2022.

Lindsley, C.W. 2017. New 2016 Data and Statistics for Global Pharmaceutical Products and Projections through 2017.

Muson, S.E., and T.G. Townsend. 2009. Pharmaceutical compound content of municipal solid waste. Journal of Hazardous Materials 162:730–735.

National Center for Health Statistics. 2013. Health, United States, 2012: With Special Feature on Emergency Care. Hyattsville, MD.

Rexam PLC. 2011. Packaging Unwrapped: Rexam Consumer Packaging Report 2011/12. Accessed January 26, 2015. https://www.yumpu.com/en/document/read/45469668/rexam-consumer-packaging-report-2011-12-packaging-unwrapped Accessed on 27 July 2021.

Wilson, B. S., V. H. Smith, F. DeNoyelles, and C. K. Larive. 2003. "Effects of three pharmaceutical and personal care products on natural freshwater algal assemblages." Environ- mental Science and Technology 37: 1713–1719.

Table 1. 

Sale of top OTC medications in the United States in 2017.

Top OTC Pharmaceutical Sales

Top OTC Personal Care Product Sales

Cough/cold and allergy remedies ($8.6 billion)

Anti-perspirants ($3.0 billion)

Analgesics and pain products ($5.0 billion)

Toothpaste ($2.8 billion)

Heartburn medicines ($2.7 billion)

First aid ($2.2 billion)

Laxatives ($1.3 billion)

 

Source: https://www.chpa.org/about-consumer-healthcare/research-data/otc-use-statistics

Table 2. 

Top 10 prescription medications by sales and number of monthly prescriptions in 2015.

   

US

Global

Product

Active Ingredient

Use

Rank

Sales (US $ Billion)

Rank

Sales (US $ Billion)

Nexium

Esomeprazole

Gastroesophageal reflux disease

1

5.64

4

7.5

Abilify

Aripiprazole

Major depressive disorder

2

5.6

7

7.0

Crestor

Rosuvastatin calcium

High cholesterol and high triglycerides in the blood

3

4.76

3

8.3

Advair Diskus

Fluticasone propionate, salmeterol xinafoate

Asthma in patients 4 years and older

4

4.62

1

8.9

Cymbalta

Duloxetine hydrochloride

Major depressive disorder and general anxiety disorder

5

4.47

10

5.8

Humira

Adalimumab

Rheumatoid arthritis, juvenile idiopathic arthritis, psoriatic arthritis, ankylosing spondylitis, and plaque psoriasis

6

4.3

2

8.5

Enbrel

Etanercept

Rheumatoid arthritis, ankylosing spondylitis, and psoriatic arthritis

7

3.99

5

7.5

Remicade

Infliximab

Rheumatoid arthritis, psoriatic arthritis, ulcerative colitis and Crohn's disease

8

3.72

6

7.3

Copaxone

Glatiramer acetate

Multiple sclerosis

9

3.33

18

4.5

Neulasta

Pegfilgrastim

Neutropenia

10

3.32

20

4.3

Rituxan

Rituximab

Non-Hodgkin's lymphoma or chronic lymphocytic leukemia

11

3.13

-

-

Singulair

Montelukast sodium

Seasonal allergic rhinitis and perennial allergic rhinitis

12

-

16

4.7

Atripla

Efavirenz, emtricitabine, and tenofovir disoproxil

Human immunodeficiency virus (HIV)

13

2.77

-

-

OxyContin

Oxycodone hydrochloride

Moderate to severe pain

14

2.69

-

-

Spiriva

Tiotropium

Breathing difficulties caused by chronic obstructive pulmonary disease (COPD)

15

2.69

13

5.1

Avastin

Bevacizumab

Patients with certain types of colorectal and lung cancers

16

2.56

11

5.4

Plavix

Clopidogrel bisulfate

Prevent blood clots after a recent heart attack

17

-

12

5.2

Januvia

Sitagliptin

Type 2 (non insulin-dependent) diabetes

18

2.5

-

-

Lantus

Insulin glargine

Type 1 (insulin-dependent) or type 2 (non insulin-dependent) diabetes

19

2.21

8

6.6

Truvada

Tenofovir disoproxil and emtricitabine

HIV

20

2.21

-

6.0

MabThera

Rituximab

Rheumatoid arthritis

 

-

9

4.3

Glivec

Imatinib mesilate

Blood cancer

28

1.7

19

 

Lipitor

Atorvastatin

High cholesterol, and to lower the risk of stroke, heart attack

31

-

14

5.1

Herceptin

Trastuzumab

Breast cancer

 

-

15

5.0

Source: https://www.webmd.com/drug-medication/news/20150508/most-prescribed-top-selling-drugs

Publication #SL419

Release Date:August 30, 2021

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About this Publication

This document is SL419, one of a series of the Department of Soil and Water Sciences, UF/IFAS Extension. Original publication date March 2015. Revised July 2018 and August 2021. Visit the EDIS website at https://edis.ifas.ufl.edu for the currently supported version of this publication.

 

About the Authors

Yun-Ya Yang, former postdoctoral researcher, Soil and Water Quality Laboratory, UF/IFAS Gulf Coast Research and Education Center; Gurpal S. Toor, former associate professor, Soil and Water Quality Laboratory, UF/IFAS GCREC; and Alexander J. Reisinger, assistant professor, Urban Ecosystems Laboratory, Department of Soil and Water Sciences; UF/IFAS Extension, Gainesville, FL 32611.

Contacts

  • Alexander Reisinger